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Caspase-3/7 Inhibitor I | CAS 220509-74-0 | SCBT - Santa ...

Caspase-3/7 Inhibitor I has only a trivial effect (K i(app) >25 μM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. It has been shown to inhibit apoptosis in camptothecin treated Jurkat cells (IC 50 ~50 μM).

Link: https://www.scbt.com/scbt/product/caspase-3-7-inhibitor-i-220509-74-0/ (Actived: Wednesday Jun 12, 2019)

APExBIO - Caspase-3/7 Inhibitor I - apexbt.com

A1920 Z-DEVD-FMK. Caspase. Z-DEVD-FMK is a tetrapeptide caspase inhibitor that is considered relatively selective for caspase-3 and has been widely used in in vitro and in vivo models of acute injury to delineate roles for caspase 3 in neuronal cell death.

Link: https://www.apexbt.com/caspase-3-7-inhibitor-i.html (Actived: Thursday Jun 13, 2019)

Caspase 3 - Wikipedia

Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9.It is encoded by the CASP3 gene.CASP3 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.. The CASP3 protein is a member of the cysteine-aspartic acid protease family.

Link: https://en.wikipedia.org/wiki/Caspase_3 (Actived: Saturday Jun 15, 2019)

Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem The ...

Sigma-Aldrich offers Sigma-Aldrich-218826, Caspase-3/7 Inhibitor I - CAS 220509-74-0 - Calbiochem for your research needs. Find product specific information including CAS, MSDS, protocols and references.

Link: https://www.sigmaaldrich.com/catalog/product/mm/218826 (Actived: Wednesday Jun 12, 2019)

Caspase-3/7 Inhibitor I (CAS 1110670-49-9) | Cayman Chemical

Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (K i (app) = 60 nM; IC 50 = 120 nM) and caspase-7 (K i (app) = 170 nM). 1 It is a weaker inhibitor of caspase-9 (K i (app) = 3.1 μM) and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (K i (app)s ≥25 μM). 1,2 Caspase-3/7 inhibitor I inhibits apoptosis in camptothecin-treated Jurkat

Link: https://www.caymanchem.com/product/14464 (Actived: Friday Feb 15, 2019)

Caspase-3 Inhibitor Z-DEVD-FMK FMK004: R&D Systems

View Caspase-3 Inhibitor Z-DEVD-FMK (FMK004) datasheet. Background: Caspase-3. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis.

Link: https://www.rndsystems.com/products/caspase-3-inhibitor-z-devd-fmk_fmk004 (Actived: Tuesday Jun 11, 2019)

Caspase-3/7 Inhibitor I | Caspase-3/7 Inhibitor | Buy ...

Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM). Double click on above image to view full picture More Views

Link: https://www.adooq.com/caspase-3-7-inhibitor-i.html (Actived: Thursday Jun 13, 2019)

Caspase 7 - Wikipedia

Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis.

Link: https://en.wikipedia.org/wiki/Caspase_7 (Actived: Friday Jun 14, 2019)

Caspase 3 | Caspase 9 inhibitors | Caspase Inhibitor

Caspase-3/7 Inhibitor I is a potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM). A14916 Z-WEHD-FMK: Caspase inhibitor : Z-WEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity.

Link: https://www.adooq.com/caspase.html (Actived: Saturday Jun 15, 2019)

Caspase-3 Inhibitor | CAS 210344-95-9 | SCBT - Santa Cruz ...

Caspase-3 inhibitor (Z-DEVD-FMK ) is a cell-permeable, potent, and irreversible inhibitor of caspase-3, caspase-6, caspase-7, caspase-8 and caspase-10. Caspase inhibitors play an important role in investigating biological processes.

Link: https://www.scbt.com/scbt/product/caspase-3-inhibitor-210344-95-9/ (Actived: Friday Jun 14, 2019)

Caspase-3/7 Fluorescence Assay Kit | Cayman Chemical

Cayman’s Caspase-3/7 Fluorescence Assay Kit employs a specific substrate, N-Ac-DEVD-N’-MC-R110, which upon cleavage by active caspase-3 or caspase-7, generates a highly fluorescent product that can be measured using excitation and emission wavelengths of 485 and 535 nm, respectively.

Link: https://www.caymanchem.com/product/10009135 (Actived: Tuesday May 21, 2019)

Caspase-3/7 Inhibitor I|Caspase-3/7 inhibitor|CAS# 220509-74-0

Z-DEVD, a selective caspase 3/7 inhibitor, didn’t affect the sensitivity of three mesothelioma-derived cell lines to cisplatin. Background. Caspase-3/7 inbibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 mM).

Link: https://apxbt.com/caspase-3-7-inhibitor-i.html (Actived: Monday Jun 3, 2019)

Caspase Substrates and Inhibitors - PubMed Central (PMC)

Caspase-7 showed activity for its expected DEVD substrate and additionally for the caspase-2 substrate (VDVAD). The most promiscuous turned out to be caspase-3, which cleaved all substrates, albeit with vastly different rates, and often with higher rates than caspases for which the substrates were designed (McStay et al. 2008).

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721276/ (Actived: Thursday Jan 26, 2017)

Caspase 3 Inhibitor - an overview | ScienceDirect Topics

Despite the shortcomings of small molecule caspase-3 inhibitors for the treatment of adult stroke, treatments that increase levels of the caspase-3/-7 inhibitor XIAP have repeatedly been shown to improve both cellular and behavioural outcome in experimental models of stroke.

Link: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/caspase-3-inhibitor (Actived: Friday May 24, 2019)

Caspase 3 Inhibitors | Biocompare.com

It is also the predominant caspase involved in cleavage of amyloid-beta, a protein well known for its role in Alzheimer's disease. Caspase-3 interacts with caspase-8 and caspase-9 and shares a substrate with caspase-7. Inhibitors of caspase-3 are in demand for cancer and neurological studies.

Link: https://www.biocompare.com/pfu/120065/soids/4727/Inhibitors/Caspase_3 (Actived: Friday Jun 7, 2019)